pentobarbital will reduce the extent or outcome of artemether/lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration with sturdy CYP3A4 inducers can lead to lowered serum concentrations and loss of antimalarial efficacySoon after stopping a CYP3A4 inducer, given that the effects… Read More